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如何更新临床指南
Updating Practice Guidelines
JAMA
PubMed (28 May 2014)
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吡非尼酮治疗特发性肺纤维化的临床3期试验
A Phase 3 Trial of Pirfenidone in Patients with Idiopathic Pulmonary Fibrosis
N Engl J Med
PubMed (29 May 2014)
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- 从1990年到2012年期间疟疾在非洲西部农村的起伏
The Rise and Fall of Malaria in a West African Rural Community, Dielmo, Senegal, from 1990 to 2012: a 22 year Longitudinal Study
Lancet Infect Dis
PubMed (Jun 2014)
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抗CTLA-4治疗癌症患者可提高患者生存率
Improved Survival with T Cell Clonotype Stability After Anti–CTLA-4 Treatment in Cancer Patients
Sci Transl Med
PubMed (28 May 2014)
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- 食管鳞状细胞癌中的基因改变
Identification of Genomic Alterations in Oesophageal Squamous Cell Cancer
Nature
PubMed (1 May 2014)
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骨髓移植后严重腹泻并不总是由移植物抗宿主反应引起的
Severe Diarrhea Following Bone Marrow Transplantation Is Not Always Caused by GVHD
Gastroenterology
PubMed (Jun 2014)
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乙型肝炎病毒感染可增强体内外腺病毒相关载体转导的易感性
Hepatitis B Virus Infection Enhances Susceptibility toward Adeno-associated Viral Vector Transduction In Vitro and In Vivo
Hepatology
PubMed (Jun 2014)
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- 胰岛素通过调节胰腺β细胞中翻译起始支架蛋白EIF4G1调控羧肽酶E
Insulin Regulates Carboxypeptidase E by Modulating Translation Initiation Scaffolding Protein eIF4G1 in Pancreatic β Cells
Proc Natl Acad Sci U S A
PubMed (3 Jun 2014)
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在女性心脏疾病患者中PDE5抑制剂的疗效具有雌激素依赖性
PDE5 Inhibitor Efficacy is Estrogen Dependent in Female Heart Disease
J Clin Invest
PubMed (2 Jun 2014)
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- RhoA蛋白可通过控制中性粒细胞的运动和限制高反应性而决定疾病进展
RhoA Determines Disease Progression by Controlling Neutrophil Motility and Restricting Hyperresponsiveness
Blood
PubMed (5 Jun 2014)
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- 对比体外循环冠脉旁路移植与非体外循环冠脉旁路移植对肾功能的影响：一项随机临床试验
Kidney Function After Off-Pump or On-Pump Coronary Artery Bypass Graft Surgery: A Randomized Clinical Trial
JAMA
PubMed (4 Jun 2014)
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通过控制发炎皮肤效应T细胞滞留CX3CL1及其受体CX3CR1来调节特应性皮炎
CX3CL1 (fractalkine) and its Receptor CX3CR1 Regulate Atopic Dermatitis by Controlling Effector T Cell Retention in Inflamed Skin
J Exp Med
PubMed (2 Jun 2014)
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DNA甲基化与身体质量指数的相关性
DNA Methylation and Body-mass Index: a Genome-wide Analysis
Lancet
PubMed (7 Jun 2014)
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与公立学校相比，美国私立学校对学校免疫要求有较高的豁免率
United States Private Schools Have Higher Rates of Exemptions to School Immunization Requirements than Public Schools
J Pediatr
PubMed (29 Apr 2014) |
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- 早期使用β受体阻滞剂治疗ST段抬高型心肌梗死与住院死亡率增加有关联
Beta-blocker Use in ST-segment Elevation Myocardial Infarction in the Reperfusion Era (GRACE)
Am J Med
PubMed (Jun 2013)
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- 非法药物滥用者尸检分析发现：可卡因滥用与高血压和缺血性肾损害有关，而炎症和钙化在静脉注射吸毒者中比较常见
Nephropathy in Illicit Drug Abusers: A Postmortem Analysis
Am J Kidney Dis
PubMed (Jun 2014)
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在经皮冠状动脉介入治疗的冠心病患者中，氯吡格雷血小板对二磷酸腺苷的反应性是引起的中风危险因素之一
Risk of Stroke in Patients With High On-Clopidogrel Platelet Reactivity to Adenosine Diphosphate After Percutaneous Coronary Intervention
Am J Cardiol
PubMed (1 Jun 2014)
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- 研究发现干细胞自我更新所必须的转录因子
Defining an Essential Transcription Factor Program for Naïve Pluripotency
Science
PubMed (6 Jun 2014)
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- 肝X受体在脂质代谢中的作用及其药物研发
Liver X Receptors in Lipid Metabolism: Opportunities for Drug Discovery
Nat Rev Drug Discov
PubMed (Jun 2014)
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- Hippo信号通路的活性可影响干细胞的命运
Hippo Pathway Activity Influences Liver Cell Fate
Cell
PubMed (5 Jun 2014)
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